منابع مشابه
Histone variants in development and diseases.
Eukaryotic genomic DNA is highly packaged into chromatin by histones to fit inside the nucleus. Other than the bulk packaging role of canonical histones with an expression peak at S phase and replication-coupled deposition, different histone variants have evolved distinct regulatory mechanisms for their expression, deposition and functional implications. The diversity of histone variants result...
متن کاملEvolving “Metazoan” Development
A paradigm system for the evolution of multicellular animals is constructed. In many evolutionary models, the non-linearity of the genome-phenome mapping is ignored. However, the results of evolutionary paradigm systems that did include a non-trivial, complex genome-phenome mapping have suggested a framework joining seemingly conflicting evolutionary “points of view” like neutral evolution, Pun...
متن کاملDynamic alterations of linker histone variants during development.
The process of development can be viewed as a series of linker histone replacements which take place throughout spermatogenesis and oogenesis, as well as following fertilization or somatic nuclear transfer (SNT). Although few of the histone H1 variants in question have been shown to be essential for viability, the timing of their appearance as well as the affinity with which they are able to bi...
متن کاملHistone variants and epigenetics.
Histones package and compact DNA by assembling into nucleosome core particles. Most histones are synthesized at S phase for rapid deposition behind replication forks. In addition, the replacement of histones deposited during S phase by variants that can be deposited independently of replication provide the most fundamental level of chromatin differentiation. Alternative mechanisms for depositin...
متن کاملHistone variants: deviants?
Histones are a major component of chromatin, the protein-DNA complex fundamental to genome packaging, function, and regulation. A fraction of histones are nonallelic variants that have specific expression, localization, and species-distribution patterns. Here we discuss recent progress in understanding how histone variants lead to changes in chromatin structure and dynamics to carry out specifi...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2010
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2010.10.014